Verastem, Inc. (VSTM) — Current Report

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Earlier Current Report filings

Filed: 2025-12-31
  • Verastem, Inc. has discontinued the RAMP 203 clinical trial in advanced KRAS G12C-mutated non-small cell lung cancer to focus resources on the development of VS-7375, an oral KRAS G12D inhibitor, in advanced NSCLC and other solid tumors.
  • The discontinued RAMP 203 trial had mixed results, with the doublet combination showing a 40% overall response rate in treatment-naive patients but only 9.5% in previously treated patients, and the triplet combination showing a 50% response rate in treatment-naive patients and 36% tumor reduction in previously treated patients.
  • The decision to discontinue RAMP 203 reflects the evolving treatment landscape for KRAS G12C inhibitors and Verastem's strategic prioritization of programs with the greatest potential impact for patients with advanced lung cancer.

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